Combatting the Organ Deficit

A Historical Investigation into Combatting Smallpox in Iran: 1948–1967 (First to Third Development Projects)

Smallpox was a dangerous disease that was considered one of the leading causes of mortality and disability in Iran up to Pahlavi II period. Therefore, combatting this disease was necessary. At the beginning of the second development plan (1955) and by founding Combatting Smallpox Service, the efforts for eradicating smallpox became more organized. This organization could overcome a lot of the d...

Combatting Tuberculosis and Homelessness: Recommendations

Water deficits uncouple growth from photosynthesis, increase C content, and modify the relationships between C and growth in sink organs.

In plants, carbon (C) molecules provide building blocks for biomass production, fuel for energy, and exert signalling roles to shape development and metabolism. Accordingly, plant growth is well correlated with light interception and energy conversion through photosynthesis. Because water deficits close stomata and thus reduce C entry, it has been hypothesised that droughted plants are under C ...

New horizons in frailty: ageing and the deficit-scaling problem.

All the current frailty measures count deficits. They differ chiefly in which items, and how many, they consider. These differences are related: if a measure considers only a few items, to define broad risks those items need to integrate across several systems (e.g. mobility or function). If many items are included, the cumulative effect of small deficits can be considered. Even so, it is not c...

Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

We report here that when untreated mice underwent heat stress, they displayed thermoregulatory deficit (e.g., animals display hypothermia during room temperature exposure), brain (or hypothalamic) inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment (e.g., decreased plasma levels of both adrenocorticotrophic hormone and corticosterone during heat stress), mul...